Innovative biomaterials for the treatment of periodontal disease

Periodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding tooth. Routine periodontal treatment includes mechanical debridement (surgical non-surgical) systemic administration antibiotics. In contrast, severe chronic periodontitis aggressive tissue bone resorption, damage usually irreversible. these cases, grafts, delivery growth hormones, guided regeneration can all be used to stimulate regeneration. However, approaches do not result in consistent predictable outcomes. As result, advanced biomaterials have evolved as an adjunctive approach improve clinical performance. These novel are designed either prolong release antibacterial agents or osteogenic molecules, act immunomodulators promote healing. The first half this review briefly summarizes key immune cells their underlying cellular pathways implicated periodontitis. Advanced will highlighted second half. Finally, limitations current experimental design challenges translational science discussed.